Research in ASV therapy: the big picture | ResMed

Research in ASV therapy

Get the big picture of adaptive servo-ventilation (ASV) therapy, with an overview of updated guidelines and evidence highlighting its benefits for patients with central sleep apnoea (CSA).

The value of registries in ASV

Although randomised controlled trials (RCTs) are useful to assess safety and efficacy of a therapy, the lack of diversity in the selected patient population can lead to gaps in clinical knowledge.5 Real-world evidence, such as registries, assess outcomes in a non-selected population, representative of the day-to-day reality of sleep clinics. Following this logic, FACE6,7 and READ-ASV8 have provided valuable new insights.

This content is intended for health professionals only.


  1. Cowie MR & al. Adaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure. New England Journal of Medicine, 2015 Sep 17;373(12):1095-105
  2. Randerath et al. Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep ERJ 2017 49: 1600959
  3. Launois Rollinat & al. Consensus français sur les syndrome d’apnées et hypopnées centrales du sommeil (SAHCS) de l’adulte. Préambule : contexte et méthodologie utilisée, Médecine du Sommeil, 2024, ISSN 1769-4493,
  4. Randerath W, Baillieul S, Tamisier R. Central sleep apnoea: not just one phenotype. Eur Respir Rev. 2024;33(171):230141. DOI: 10.1183/16000617.0141-2023
  5. Reynor A, McArdle N, Shenoy B, Dhaliwal SS, Rea SC, Walsh J, Eastwood PR, Maddison K, Hillman DR, Ling I, Keenan BT, Maislin G, Magalang U, Pack AI, Mazzotti DR, Lee CH, Singh B. Continuous positive airway pressure and adverse cardiovascular events in obstructive sleep apnea: are participants of randomized trials representative of sleep clinic patients? Sleep. 2022 Apr 11;45(4):zsab264. doi: 10.1093/sleep/zsab264. PMID: 34739082; PMCID: PMC9891109.
  6. Tamisier R et al. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort. Sleep Med. 2024 doi:10.1016/j.sleep.2023.07.014
  7. Tamisier R et al. Adaptive servo ventilation for sleep apnoea in heart failure: the FACE study 3-month data. Thorax. 2022 doi:10.1136/thoraxjnl-2021-217205
  8. Arzt M et al. Effects of Adaptive Servo-Ventilation on Quality of Life: The READ-ASV Registry. Ann Am Thorac Soc. 2024 doi:10.1513/AnnalsATS.202310-908OC

Last update: 06/2024